 | Vita and Virginia (2018) |
 | Incredibles 2 (2018) as Ambassador (voice) |
 | Larger than Life: The Kevyn Aucoin Story (2017) as Herself |
 | Così parlò De Crescenzo (2017) |
 | Le cinéma dans l'oeil de Magnum (2017) as Interviewee |
 | Blue Velvet Revisited (2016) as Herself |
 | Closet Monster (2016) as Buffy |
 | Dennis Hopper: Uneasy Rider (2016) as Herself |
 | Joy (2015) as Trudy |
 | Viva Ingrid! (2015) |
 | The 1000 Eyes of Dr Maddin (2015) |
 | Leslie Howard: The Man Who Gave a Damn (2015) as Herself (Voice) |
 | Jag är Ingrid (2015) as Herself |
 | Isabella Rossellini's Green Porno Live (2015) as Herself |
 | Enemy (2013) as Adam's Mother |
 | Trespassing Bergman (2013) as Herself |
 | Mammas (2013) |
 | Nono, the Zigzag Kid (2012) as Lola Ciperola |
 | Du vent dans mes mollets (2012) as Madame Trebla |
 | About Face: Supermodels Then and Now (2012) as Herself |
 | BAM150 (2012) as Isabella Rossellini |
 | Poulet aux Prunes (2011) as Parvine |
 | Keyhole (2011) as Hyacinth |
 | Late Bloomers (2011) as Mary |
 | La solitudine dei numeri primi (2010) as Adele |
| | Isabella Rossellini - Aus dem Leben eines Schmetterlings (2010) as Herself |
 | La traversée du désir (2009) |
 | Send Me to the 'Lectric Chair (2009) |
 | My Dog Tulip (2009) as Ms. Canvenini (voice) |
 | Two Lovers (2008) as Ruth |
 | Infected (2008) as Carla Plume |
 | The Accidental Husband (2008) as Greta Bollenbecker |
| | Beyond Wiseguys: Italian Americans & the Movies (2008) |
 | Brand Upon the Brain! (2007) as Interlocuter |
 | The Last Jews of Libya (2007) as Herself |
 | The Architect (2006) as Julia Waters |
 | Infamous (2006) as Marella Agnelli |
 | La Fiesta del Chivo (2006) as Urania |
 | A Life in Suitcases (2005) as Madame Moitessier |
| | Notes on My Father: An Interview with Isabella Rossellini (2005) |
 | My Dad Is 100 Years Old (2005) as Herself / Alfred Hitchcock / David O. Selznick / Federico Fellini / Charlie Chaplin / Ingrid Bergman |
 | Heights (2005) as Liz |
 | The Tulse Luper Suitcases, Part 2: Vaux to the Sea (2004) as Madame Moitessier |
 | The Saddest Music in the World (2003) as Lady Helen Port-Huntley |
 | The Tulse Luper Suitcases, Part 1: The Moab Story (2003) as Mme. Moitessier |
 | Monte Walsh (2003) as 'Countess' Martine |
 | Empire (2002) as La Colombiana |
 | Roger Dodger (2002) as Joyce |
 | Mysteries of Love (2002) as Herself |
 | Don Quixote (2000) as The Duchess |
 | Il Cielo Cade (2000) as Katchen |
 | The Impostors (1998) as The Veiled Queen |
 | Left Luggage (1998) as Mrs. Kalman |
 | Big Night (1996) as Gabriella |
 | Crime of the Century (1996) as Anna Hauptmann |
 | Ingrid Bergman Remembered (1996) as Herself |
 | The Funeral (1996) as Clara Tempio |
 | Immortal Beloved (1994) as Anna Marie Erdödy |
 | Wyatt Earp (1994) as Big Nose Kate |
 | Fearless (1993) as Laura Klein |
 | The Innocent (1993) as Maria |
 | The Pickle (1993) as Planet Cleveland Woman (uncredited) |
 | Sex (1992) as Herself |
 | Death Becomes Her (1992) as Lisle von Rhoman |
 | Lies of the Twins (1991) as Rachel Marks |
 | Dames galantes (1990) as Victoire |
 | Ivory Hunters (1990) as Maria DiConti |
 | Wild at Heart (1990) as Perdita Durango |
 | Cousins (1989) as Maria Hardy |
 | Red Riding Hood (1989) |
 | Zelly and Me (1988) as Mademoiselle Zelly |
| | No Frank in Lumberton (1988) |
 | Siesta (1987) as Marie |
 | Tough Guys Don't Dance (1987) as Madeleine Regency |
 | Blue Velvet (1986) as Dorothy Vallens |
 | White Nights (1985) as Darya Greenwood |
 | Il Pap'occhio (1980) as Isabella |
 | Il Prato (1979) as Eugenia |
 | A Matter of Time (1976) as Sister Pia |
| | Mammas Director |
| | Isabella Rossellini - Aus dem Leben eines Schmetterlings Director |
| | My Dad Is 100 Years Old Writer |
| | Il Pap'occhio Actor |